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KMID : 0378019930360030034
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New Medical Journal
1993 Volume.36 No. 3 p.34 ~ p.38
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A Clinical Study of Recombinant Human G-CSF in Advanced Gastric and Colorectal Cancer Patients with Neutropenia Due to Chemotherapy
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Abstract
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We conducted a prospective study of determine the efficacy and safety of recombinant human granulocyte colony-stimulating factor (G-CSF) after second course of EAP (etoposide, adriamycin, cisplatin) chemotherapy in 8 patients with advanced gastric cancer and after second course of ACNU+UFT chemotherapy in 2 patients with advanced colorectal carcinoma.
Treatment with G-CSF (2 ?/kg/day) accelerated the recovery of neutrophils and leukocyte significantly. The lowest neutrophil count during treatment with G-CSF were significantly higher than control cycles (1645±242/mm3. v.s. 750±184/mm3). There were on difference in lymphocyte, moncyte and platelet counts between no difference in lymphocyte. monocyte and platelet counts between control cycle and the cycle treated with G-CSF. The ability of the growth factor to reduce severe neutropenia suggests it will have an important role in the management of solid gastrointestinal cancers.
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KEYWORD
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